CTCFL/BORIS fall into the category of Cancer/Testis (CT) antigens (CTCFL/BORIS; CT27), a group of tumor associated genes aberrantly expressed in many cancers, but with restricted expression confined to the testis in their normal state, thus belonging to a group of genes suggested to represent targets for future cancer vaccine development [16, 17]. The gene discussed is CTCFL; the disease is neoplasm.