For instance, loss of tumor suppressor genes such as Bin-1 in tumors drives IDO induction via STAT1 and nuclear factor kB [1], two signaling molecules that have been identified to be key for the inducible IDO expression in myeloid and mesenchymal cells via IFN-g and toll-like receptor (TLR) ligands [31]. This evidence concerns the gene BIN1 and neoplasm.