Owing the role recently ascribed to Wnt-pathway activation in IBD-associated carcinogenesis [22], we finally examined the expression and subcellular localization of β-catenin, E-cadherin, APC, c-Myc and Cyclin-D1, in rat colonic mucosae resected at the 6th-8th weeks after the first DMH administration (histologically classified as IBD), and in human specimens from patients suffering from IBD (Chron's disease or ulcerative rectocolitis). Here, CCND1 is linked to inflammatory bowel disease.