Indeed, we recorded, already in IBD and in early stages of neoplastic transformation (LD and HD), changes in the expression and tissue distribution of these molecules, indicative of Wnt/ß-catenin pathway activation, while Cyclin-D1 was modified at later stages, in IS and, even more, in K. Indeed, the Wnt/ß-catenin pathway have an active role from IBD to IS, with upstream and downstream events of Wnt signaling wholly activated at the IS stage, while in advanced carcinoma the role of this pathway seems to overshadow, as indicated by the absence on nuclear ß-catenin. The gene discussed is CCND1; the disease is Huntington disease.