Owing the role recently ascribed to Wnt-pathway activation in IBD-associated carcinogenesis [22], we finally examined the expression and subcellular localization of β-catenin, E-cadherin, APC, c-Myc and Cyclin-D1, in rat colonic mucosae resected at the 6th-8th weeks after the first DMH administration (histologically classified as IBD), and in human specimens from patients suffering from IBD (Chron's disease or ulcerative rectocolitis). The gene discussed is CDH1; the disease is inflammatory bowel disease.