Indeed, in rat IBD tissues Cyclin-D1 resulted dramatically up-regulated vs NM (10-fold for total expression), and in all samples analyzed this onco-protein localized in the nucleus of 10-50% of colonic epithelial cells (4 out of 5 samples) or in more than 50% of cells (1 sample) (Figure 6B). This evidence concerns the gene CCND1 and inflammatory bowel disease.