PEA15 and cancer: PEA-15 is known to be upregulated in a variety of cancer subsets including immortal cancer cell lines (e.g. MCF-7 and HeLa cells) (Condorelli et al., 1999), malignant pleural mesothelioma cells (Kuramitsu et al., 2009), breast cancer cells (Stassi et al., 2005), non-small cell lung cancer (NSCLC) cells (Zanca et al., 2008), glioblastoma (Eramo et al., 2005) and renal cell carcinomas (Heikaus et al., 2008).