Recently, microRNA-212 has been suggested to be a negative regulator of PEA-15 in NSCLC as overexpression of the microRNA resulting in a reduction in PEA-15 protein levels and increased TRAIL-mediated apoptosis, suggesting they are inversely correlated (Incoronato et al., 2010). This evidence concerns the gene PEA15 and non-small cell lung carcinoma.