Our work showed the hsa04110 pathway (cell cycle) was significantly abnormal in osteoporosis, which including the two down-regulated genes, CCNA2 and CCNB1, CCNA2 as a general regulator of cell cycle is the main A-type cyclin presenting in somatic cells and a mediator of the cell cycle [21]. The gene discussed is CCNB1; the disease is osteoporosis.