OSBPs have been implicated in both AD and ATH [330,331]; oxysterol binding to OSBPs in macrophages is thought to play a direct role in atheromatous plaque formation [332] and macrophage expression of OSBP2 (OSBP-L1) enhances ATH in susceptible mice [331]. The gene discussed is OSBP2; the disease is Alzheimer disease.