In support of a role of CH25H enzyme in both diseases, GWAS studies have implicated the gene cluster cholesterol 25-hydroxylase, CH25H (10q23) – lipase A, lysosomal acid, cholesterol esterase, LIPA (10q23.2-q23.3) in both ATH [335,336] and AD [337,338]. The gene discussed is CEL; the disease is Alzheimer disease.