CX3CR1 genetic depletion was found to protect from neuronal loss in the 3xTg-AD model[37] and reduce β-amyloid deposition by activating its phagocytosis in CRND8, APPPS1 and R1.40 mice[35,36], whereas it exacerbates tau phosphorylation and aggregation, and enhances cognitive deficits in hTau and hAPP mice[65,66]. The gene discussed is MAPT; the disease is Alzheimer disease.