In agreement with the extensive body of evidence showing an imbalance in cytokine and/or chemokine production in the blood, CSF or brain of individuals diagnosed with AD[57], we observed a rise in the ratios of IL-5, IL-12, MCP-1 and GM-CSF over IL-10 in the brain of 3xTg-AD mice. This evidence concerns the gene IL5 and Alzheimer disease.