Schlotzer-Schrehardt et al. reported MMP-2/TIMP-2 ratios of 1.4 in POAG and 1.0 in control patients, and MMP-2 + MMP-3 to TIMP-1 + TIMP-2 ratios of 0.15 in POAG and 0.14 in control patients [7]. The gene discussed is MMP3; the disease is open-angle glaucoma.