BNP levels in adults strongly correlate with the New York Heart Association (NYHA) functional classification of patients with heart failure and have been shown to act as an independent predictor of adverse outcome [23]. N-terminal pro-brain natriuretic peptide (NT-pro-BNP), an inactive by-product resulting from the synthesis of BNP, is another member of the natriuretic peptide family [21]. Here, NPPB is linked to heart failure.