The over expression of miR-630 in the pancreatic cancer cell line PANC-1 has recently been associated with decreased mRNA and protein levels of IGF1R as well as enhanced apoptosis [16] while the motility and invasion of the ANGPTL1 over-expressing lung cancer cell line (CL1-5/ANGPTL1) has been shown to be restored following miR-630 inhibition [15]. The gene discussed is IGF1R; the disease is familial pancreatic carcinoma.