OLR1 and fibrosis: In cardiac fibroblasts, LOX-1 activation has been linked to collagen synthesis via an interaction between LOX-1-NADPH oxidase-TGFβ (Transforming Growth Factor beta) leading to an activation of the Mitogen-activated protein kinase (MAPK) pathway [21] establishing a possible link between the OxLDL signaling pathway and irreversible tissue fibrosis.