In the Asian subgroup, no significant association between TAP1 I333V gene polymorphism and T1DM was found in the allelic (OR: 1.69, 95% CI: 0.86–3.34, P = 0.13), recessive (OR: 0.928, 95% CI: 0.222–3.873, P = 0.918), dominant (OR: 2.133, 95% CI: 0.815–5.583, P = 0.123), homozygous (OR: 1.235, 95% CI: 0.293–5.211, P = 0.773) and heterozygous genetic models (OR: 2.141, 95% CI: 0.773–6.248, P = 0.164). Here, TAP1 is linked to type 1 diabetes mellitus.