By two independent samples tests of nonparameter of statistic analysis, it was found that the average BSV of CD133 mRNA in the group of patients with GC was significantly higher than that in the group of volunteers (Z = −4.132, P < 0.001) or in the group of patients with GU (Z = −3.688, P < 0.001), respectively, but there was no statistic difference between the group of volunteers and the group of patients with GU (Z = −0.695, P = 0.487). This evidence concerns the gene PROM1 and gastric cancer.