Wild et al found that the combination of six biomarkers had a sensitivity equal to fecal immunohistochemical testing for the early detection of colorectal cancer, CEA showing the best sensitivity at 95%, with a specificity of 43.9% followed by seprase (42.4% sensitivity), CYFRA 21-1 (35.5%), osteopontin (30.2%), ferritin (23.9%) and anti-p53 (20.0%) [15]. This evidence concerns the gene CEACAM5 and colorectal cancer.