CAMK2G and hydrops fetalis: While the increase in INaL may play a role in the observed [Na+]i loading in these transgenic mice (Wagner et al., 2006), we demonstrated that CaMKII-dependent enhancement of INaL is not quantitatively sufficient to account for the [Na+]i elevation observed in HF (Grandi et al., 2007; Wagner et al., 2011; Moreno et al., 2013; Morotti et al., 2014).