OPRK1 and alcohol dependence: These remarkable findings have propelled the design and development of new small molecule, functionally selective KOR antagonists (Zhou et al., 2013) that may prove efficacious in managing the hedonic dysregulation associated with drug and alcohol dependence (Koob and Le Moal, 1997; Kenny et al., 2006; Potter et al., 2011; Walker et al., 2012).