Evidence in this field is available also for neurodegenerative diseases: a study conducted on FTLD with TDP-43 inclusions (FTLD-TDP) by Rademakers et al. (2008) unveiled a functional effect for the high-risk allele of rs5848 in progranulin gene (GRN), which promotes a more efficient binding of miR-659, resulting in augmented translational inhibition of GRN. Here, GRN is linked to neurodegenerative disease.