FGF20 and Parkinson disease: The risk allele was described to disrupt a binding site for miR-433, increasing FGF20 levels in vitro and in vivo, and the increase was correlated with α-synuclein overexpression, which had previously been implicated in PD pathophysiology (Wang et al., 2008b), though a later study failed to confirm the association of this SNP with PD (de Mena et al., 2010).