SHANK3 and Anxiety: In the zero-maze, a reduction in the level of anxiety, characterized by a significant increase in the time that was spent in the open arcs, was observed in both C57 and FVB Shank3 mutant animals, whereas no difference (Wang et al., 2011; Yang et al., 2012) or a decrease (Peça et al., 2011) has been reported previously.