CSF1R and neoplasm: Many different CSF1R kinase inhibitors have been tested on various mouse disease models with some effect on bone: JNJ-28312141 prevented tumor-induced osteoclastogenesis and bone erosion [35]; Ki20227 inhibited osteolytic bone destruction through the suppression of CSF1-induced OCL accumulation in vivo [36]; SU11248 caused in vivo inhibition of osteolysis [37]; and one of the most-used CSF1R inhibitors, GW2580, completely inhibited bone degradation in cultures of human OCLs, rat calvaria, and rat fetal long bone [38].