Consistent with enhanced tumor-initiating properties, we observed that the transcription factors associated with cell pluripotency and EMT, i.e., Snail, Slug, Twist, Zeb-1, Nanog, and Oct-4 were significantly increased by RT-PCR in PC cells cocultured with Mo-MDSC. The gene discussed is POU5F1; the disease is pachyonychia congenita.