For example, women who learned that they had a 29 % lifetime risk of Alzheimer’s disease based on ApoE4-negative genotype reported a much more positive response to this information as well as reduced perception of risk and reduced anxiety, compared with women who learned that their risk was 29 % based only on family history and gender (LaRusse et al. 2005). This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.