Furthermore, whether acs-3 or nhr-25 act with genes that regulate antimicrobial peptide expression specifically in response to fungal infection and epidermal damage (sta-2, snf-12, nipi-3, dapk-1) [27], [55], [56], and osmotic stress (wnk-1-gck-3 signaling) [29] needs to be determined. This evidence concerns the gene DAPK1 and fungal infectious disease.