Many of those more frequent in BRAFmut/MSS cancers, for example deletions at 6p25.1-6p21.33 and at specific loci on 17q where several Wnt regulatory genes reside (RNF43, AXIN2 and SOX9)[59], [60], [61], have not commonly been associated with CRC. This evidence concerns the gene RNF43 and colorectal carcinoma.