Several genomic regions containing fragile sites, such as the FHIT gene locus at 3p14.2, RBFOX1 at 16p13.3 and MACROD2 at 20p12.1 that were targeted for deletion in MSS cancers, were also relatively commonly deleted in BRAFmut/MSI cancers [56], [57]. The gene discussed is MACROD2; the disease is cancer.