The discrepancy between IL-6 and TNF-α expression in human skeletal muscle, and the results of our cell culture and animal work in terms of SAA1 expression might be explained by differences in timing; early biopsies were performed at median day 5, animal experiments were performed after 24 hours of sepsis and cytokine treatment was performed for 16 hours in vitro. This evidence concerns the gene SAA1 and Sepsis.