Importantly, when interrogating the most significant five SNPs associated with ΔPOST, we also identified an association between the aldehyde dehydrogenase 1 family member L1 gene (ALDH1L1) and incident ischemic stroke in the FHS cohort (rs10934753, hazard ratio = 1.26, p = 0.015, n = 168 cases 4008 controls, analyses adjusted for age, sex and family relationships). Here, ALDH1L1 is linked to ischemic stroke.