ATRX and neoplasm: Interestingly, a role for ATRX in facilitating replication through potential G-quadruplex forming sequences may shed light on its recently ascribed role as a tumor suppressor in a specific subset of malignancies that depend on a telomerase-independent pathway of telomere maintenance called the ‘alternative lengthening of telomeres’ (ALT) pathway [12], [14], [20].