EGF and breast cancer: The six breast cancer-associated mutations in the ADAM12-L protein include the D301H mutation in the metalloproteinase domain, G479E in the disintegrin domain, T596A and R612Q in the cysteine-rich domain, G668A in the epidermal growth factor (EGF)-like domain, and L792F in the cytoplasmic tail [13]–[15] (Figure 1A).