Also, in patients with non-alcoholic fatty liver disease, the VAI is linked to significant fibrosis [17], [18], while it is not more powerful than WC in discriminating steatosis from steatohepatitis [19]; in patients with HCV, the VAI showed an independent association with both steatosis and necroinflammatory activity and has a direct correlation with viral load [20]; in patients with acromegaly, the VAI appears to be associated with disease activity, adiponectin levels and insulin sensitivity and secretion, and is influenced independently of GH levels [21]. The gene discussed is INS; the disease is steatosis.