Specifically, significantly detected pathway GO terms include cytokine signaling (FASL, BMP7, CXCL4, CXCL6, CXCL14, EDAR, IL10RA, IL10, TNFRSF1B, TNFRSF11B, TNFRSF19), pathways in cancer (FASL, GLI3, AXIN2, FGF3, FGF9, FGF19, LEF1, WNT6, WNT11), or Hedgehog signaling pathway (GLI3, BMP7, WNT6, WNT11) (Table 2). The gene discussed is GLI3; the disease is cancer.