CDC42 and Parkinson disease: Other affected pathways include protein import into the nucleus, known to be impaired in degenerative proteinopathies due to mutations in HNRNP A/B [50] as well as regulation of the neuro-immune CDC42 Rho GTPase; in the brain, CDC42 binds to collybistin and participates in bringing GABAergic receptors to anxiolytic synapses [100], whereas in lymphocytes it regulates cell division [101], perhaps explaining part of the immune mal-functioning that is a characteristic PD phenotype.