TUBB3 and Parkinson disease: Validation in both brain regions by qRT-PCR of the disease RNA-Seq detected differential expression of the lncRNA RP11-79P5.3 (LncBTF3-4, which is conserved in the zebra fish) have confirmed its observed PD leukocyte up-regulation in PD brains as well (Figure 2E and 2F; two-tailed t-test p = 0.03, TUBB3 served as a reference gene).