For example, miR-125a and miR-125b, both of which are often duplicated and/or overexpressed in DLBCL, were shown to activate NF-κB by targeting the A20 [39] and NF-κB-mediated dysregulation of miRNAs observed in lymphoma[40]. The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.