Future opportunities for GHSR1a research are four-fold: (1) to define the mechanism underlying the tissue specific response in GHSR1a-mediated intracellular signaling; (2) to examine the tissue specificity of GHSR1a constitutive activity and ligand-induced response and their physiological relevance; (3) to explore the integrative function of GHSR1a in the intricate regulatory network governing energy metabolism and metabolic homeostasis; (4) to evaluate the potential applications of GHSR1a agonists, antagonists or inverse agonist in the treatment of obesity and its related metabolic diseases. This evidence concerns the gene GHSR and Other metabolic disease.