TGFB1 and Familial prostate cancer: Whereas in gastric cancer cells ATBF1 is located in the cytoplasm and can be tanslocated into the nucleus with RUNX3 upon TGFβ activation [19], we found that ectopically expressed ATBF1 is localized in the nucleus in 22Rv1 prostate cancer cells (Fig. 1) as in normal cells.