While a previous study has demonstrated that ATBF1 translocates to the nucleus with RUNX3 in response to TGFβ stimulation in gastric cancer cells [19], the mechanisms controlling the cellular localization of ATBF1 remain to be illustrated, and whether posttranslational modifications of ATBF1 depend on or determine its nuclear localization is unknown. This evidence concerns the gene ZFHX3 and gastric cancer.