In support of this, almost no FV antigen-reactive IFN-γ production from CD8+ T cells was detected when FV-infected mice were later challenged with FBL3 tumor cells, a potent inducer of FV-specific CD8+ T cell responses, and the cells were restimulated with the MHC class I-restricted viral antigenic peptide (Figure S1C, D). Here, CD8A is linked to neoplasm.