CD8A and neoplasm: Importantly, however, following challenge with FV antigen-bearing FBL3 tumor cells, minimal evidence of FV-specific tetramer binding on CD8+ T cells was observed in mice transplanted with FV-infected thymuses, while control mice transplanted with uninfected thymuses showed significantly higher levels of FV-specific CD8+ T cell expansion at the peak of response (Figure 5C, D).