The inverse RBP4 - E-selectin relation was reproduced in patients aged ≤55 but not > 55 years, and in those with but not without ≥2 major traditional cardiovascular risk factors, a Framingham score of ≥2, overall and abdominal obesity, an RA duration of >10 years, absent or mild disease activity, an erythrocyte sedimentation rate of >12 mm/hr and black ethnicity; RBP4 concentrations were not significantly associated with those of E-selectin in patients with and without carotid artery plaque. The gene discussed is SELE; the disease is rheumatoid arthritis.