DPP4 and Insulin resistance: Another pivotal aspect by which TRIB3 seems to be associated with the evolution of insulin resistance and pancreas degradation is its role in inducing apoptosis in pancreatic β-cells and inhibiting cell proliferation; so, by downregulating the expression of TRIB3, sitagliptin promotes antiapoptotic effects and enhance β-cell proliferation, thus contributing to the beneficial effects afforded by this DPP-IV inhibitor in this animal model.