At baseline, the two groups did not differ regarding anthropometric data, duration of diabetes and insulin treatment, BMI, waist circumference, body weight, HbA1c value, FBG, P2BG, plasma lipid concentration, daily insulin dose, frequency of insulin injections, combined anti-diabetic agents, C-peptide concentration and HMW adiponectin levels. The gene discussed is INS; the disease is diabetes mellitus.