Furthermore, we examined the prognostic implication of the combination status of NS and p53 and the significance of NS expression status among the three biological subtypes of breast tumors: (a) hormone-receptor (HR) positive (luminal type); (b) human epidermal growth factor receptor 2 (HER2) positive (HER2 type); and (c) HR negative and HER2 negative (triple negative). Here, ERBB2 is linked to breast neoplasm.