CDH17 and pleomorphic xanthoastrocytoma: Even taking this limitation into consideration, gene ontology analyses of the changes identified between malignant PXA and normal brain, were observed to be preferentially affecting genes involved in neuronal regulation, including response to stimulus or protein phosphorilation; in addition to pathways related with oncogenic progression, including cell motility and cell adhesion -cadherin and integrin signaling pathways-, cell proliferation -Wnt signaling components-, and angiogenesis among the affected signaling circuits (Figure 4).