For instance, loss of heterozygosity at chromosomal regions 3p21.3 (site of RASSF1A, a member of the Ras association domain family, and FUS1), 3p14.2 (FHIT, a fragile histidine triad gene), 9p21 (p16), and 17p13 (p53) was identified as an early event in the development of non-small cell lung cancer [48]. This evidence concerns the gene FHIT and non-small cell lung carcinoma.