In addition, HSP47 expression is higher in the lungs of patients with idiopathic usual interstitial pneumonia (UIP) than in those with collagen vascular disease-associated UIP and idiopathic NSIP[22]; idiopathic fibrotic NSIP patients with higher HSP47 expression in their lungs had poorer prognosis than patients with lower HSP47 expression[27]. This evidence concerns the gene SERPINH1 and idiopathic pulmonary fibrosis.