These microRNAs are also responsible for gefitinib-induced apoptosis and the epithelial-mesenchymal transition of NSCLC cells in vitro and in vivo by inhibiting the expression of the genes encoding BCL2-like 11 (BIM), apoptotic peptidase activating factor 1 (APAF-1), protein kinase C ε (PKC-ε) and sarcoma viral oncogene homolog (SRC) [42]. This evidence concerns the gene PRKCE and non-small cell lung carcinoma.