ER expression exhibited a negative correlation with age, tumor size and histological grade (χ2=4.9284, P=0.0260; χ2= 4.3281, P=0.0370; and χ2=4.1706, P=0.0410, respectively), PR expression exhibited a negative correlation with age and histological grade (χ2=10.6550, P=0.0011 and χ2=4.1649, P=0.0410, respectively) and the double-positive expression of ER and PR also exhibited a negative correlation with age and histological grade (χ2=8.6617, P=0.0033 and χ2=4.1141, P=0.0430, respectively). The gene discussed is ESR1; the disease is neoplasm.