In the present study, we used an immunohistochemical approach to investigate the correlation between OAT2 and RFC1 expression and histological response to preoperative UFT-based (UFT or UFT/LV) chemotherapy in colorectal cancer, with the aim of identifying predictive biomarkers for the efficacy of UFT/LV chemotherapy. This evidence concerns the gene SLC22A7 and colorectal cancer.