Multivariate analysis of the covariates with P<0.05 in Table III, indicated that FOXP3 expression in TILs (HR: 4.96; 95% CI: 1.07–23.06; P=0.041) was an independent prognostic factor for OS, unlike FOXP3 localization in tumor cells (cytoplasm, HR: 2.68; 95% CI: 0.90–7.97; P=0.077; and nucleus, HR: 0.15; 95% CI: 0.02–1.16; P=0.070) (Table IVB). The gene discussed is FOXP3; the disease is neoplasm.