Patients exhibited significant differences in Kaplan-Meier curves in OS (log-rank test, P<0.001; Fig. 2F), demonstrating a more detrimental effect on the prognosis of patients exhibiting cytoplasmic FOXP3+ tumor cells as well as a high infiltration of FOXP3+ lymphocytes, compared to the effect of either factor alone. The gene discussed is FOXP3; the disease is neoplasm.