For example, wild-type FOXP3 from normal cells, unlike mutated FOXP3 from cancer cells, bound to and transcriptionally repressed human epidermal growth factor receptor (HER) 2 and S-phase kinase-associated protein (SKP) 2 (16,18) or c-Myc (17) oncogenes involved in mammary or prostate carcinogenesis, respectively. The gene discussed is FOXP3; the disease is cancer.