By contrast, the expression of several tumor suppressor genes [comprising death-associated protein (DAP), phosphatase and tensin homolog (PTEN) and Ras association (RalGDS/AF-6) domain family member 1 (RASSF1A)] was downregulated in leiomyosarcoma specimens compared to leiomyoma. This evidence concerns the gene RASSF1 and leiomyoma.