On the other hand, MJ may also fights inflammation by blocking the proinflammatory 5-LOX-pathway [47] (Figure 3); 5-LOX is the first enzyme in the 5-lipoxygenase metabolic pathway leading to the synthesis of 5-HETE and leukotrienes, which are harmful proinflammatory substances having direct influence on a number of inflammatory chronic disease processes, including allergic reactions [180], and cancer progression (5-LOX is overexpressed in many aggressive types of cancer, as discussed in the 2.7 section). The gene discussed is ALOX5; the disease is cancer.