J7, a synthetic analogue of MJ, enhanced TRAIL-mediated apoptosis through upregulation of ROS levels in human hepatoma HepG2 cells; apoptosis was induced via Bid cleavage, downregulation of X-linked inhibitor of apoptosis protein (XIAP), cellular inhibitor of apoptosis-1 (cIAP-1), B-cell lymphoma-extra large (Bcl-xL), and activation of caspases [35]. Here, BIRC2 is linked to hepatocellular carcinoma.