IGFBP3 and type 1 diabetes mellitus: In this study, a group of thirty male children and adolescents with T1D with different pubertal status (prepubertal, pubertal, and postpubertal) were enrolled and compared with a group of 30 age, sex, and pubertal age matched healthy subjects with the aim of detecting differences in height and in serum concentrations of IGF-1 and IGFBP-3 [58].