Our key findings were as follows: (1) specific STAT4 polymorphisms and haplotypes were significantly associated with PBC susceptibility or protection; (2) there were no significant genetic associations between IL12A and IL12RB SNPs and PBC susceptibility, in contrast to studies of Caucasians; [8–11] and (3) there was a moderate relationship between STAT4 SNPs and ANA-positive, but not AMA-positive, PBC patients. Here, STAT4 is linked to primary biliary cholangitis.