Whereas the IL12A and IL12RB SNPs were not associated with PBC, the rs7574865 SNP in STAT4 showed a positive association with PBC susceptibility (41.9% versus 33.5%; P = 4.0 × 10−4, OR = 1.43, 95% CI = 1.17–1.74). This evidence concerns the gene IL12A and primary biliary cholangitis.