Accordingly, patients suffering from systemic vasculitis with renal involvement had a significantly lower expression of CD122 on Tregs when compared to patients with localized, nonrenal vasculitis (CD4+CD25+FoxP3+ Tregs: %CD122+  34 ± 19% versus 49 ± 10%, P = 0.04, Figure 5(d)). Here, IL2RB is linked to necrotizing vasculitis.